Produção Nacional
Revisado por pares
Potential Biomarkers for Feed Efficiency-Related Traits in Nelore Cattle Identified by Co-expression Network and Integrative Genomics Analyses
2020; Frontiers Media; Volume: 11; Linguagem: Inglês
10.3389/fgene.2020.00189
ISSN1664-8021
AutoresAndressa Oliveira de Lima, James E. Koltes, Wellison Jarles da Silva Diniz, Priscila Silva Neubern de Oliveira, Aline Cesar, P. C. Tizioto, Juliana Afonso, Marcela Maria de Souza, Juliana Petrini, M. I. P. Rocha, Tainã Figueiredo Cardoso, Adhemar Zerlotini Neto, Luiz Lehmann Coutinho, Gérson Barreto Mourão, Luciana Correia de Almeida Regitano,
Tópico(s)Genetic Mapping and Diversity in Plants and Animals
ResumoFeed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors ELF1, ELK3, ETS1, FLI1 and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1 and OGN were associated with multiple feed efficiency-related traits (FDR ≤ 0.05) and were previously related to glucose homeostasis, oxidative stress, fat mass and osteoblastogenesis, respectively. Potential regulatory elements were identified, integrating the hub genes with previous studies from our research group, such as the putative cis-regulatory elements (eQTLs) inferred as affecting the PCDH18 and SPARCL1 hub genes related to immune system and adipogenesis, respectively. Therefore, our analyses contribute to a better understanding of the biological mechanisms underlying feed efficiency in bovine and the hub genes disclosed can be used as biomarkers for feed efficiency-related traits in Nelore cattle.
Referência(s)