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Yttrium-Doped Iron Oxide Nanoparticles for Magnetic Hyperthermia Applications

2020; American Chemical Society; Volume: 124; Issue: 12 Linguagem: Inglês

10.1021/acs.jpcc.9b11043

1932-7455

Przemysław Kowalik, J. Mikulski, Anna Borodziuk, Magdalena Duda, Izabela Kamińska, Karolina Zajdel, Jarosław Rybusiński, Jacek Szczytko, Tomasz Wojciechowski, Kamil Sobczak, R. Minikayev, Magdalena Kulpa-Greszta, Robert Pązik, Paulina Grzaczkowska, K. Fronc, M Łapiński, Małgorzata Frontczak‐Baniewicz, Bożena Sikora,

Iron oxide chemistry and applications

Magnetic nanoparticles of Fe3O4 doped by different amounts of Y3+ (0, 0.1, 1, and 10%) ions were designed to obtain maximum heating efficiency in magnetic hyperthermia for cancer treatment. Single-phase formation was evident by X-ray diffraction measurements. An improved magnetization value was obtained for the Fe3O4 sample with 1% Y3+ doping. The specific absorption rate (SAR) and intrinsic loss of power (ILP) values for prepared colloids were obtained in water. The best results were estimated for Fe3O4 with 0.1% Y3+ ions (SAR = 194 W/g and ILP = 1.85 nHm2/kg for a magnetic field of 16 kA/m with the frequency of 413 kHz). The excellent biocompatibility with low cell cytotoxicity of Fe3O4:Y nanoparticles was observed. Immediately after magnetic hyperthermia treatment with Fe3O4:0.1%Y, a decrease in 4T1 cells' viability was observed (77% for 35 μg/mL and 68% for 100 μg/mL). These results suggest that nanoparticles of Fe3O4 doped by Y3+ ions are suitable for biomedical applications, especially for hyperthermia treatment.