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Abundant HIV-infected cells in blood and tissues are rapidly cleared upon ART initiation during acute HIV infection

2020; American Association for the Advancement of Science; Volume: 12; Issue: 533 Linguagem: Inglês

10.1126/scitranslmed.aav3491

1946-6242

Louise Leyre, Eugène Kroon, Claire Vandergeeten, Carlo Sacdalan, Donn Colby, Supranee Buranapraditkun, Alexandra Schuetz, Nitiya Chomchey, Mark de Souza, Wendy Bakeman, Rémi Fromentin, Suteeraporn Pinyakorn, Siriwat Akapirat, Rapee Trichavaroj, Suthat Chottanapund, Sopark Manasnayakorn, Rungsun Rerknimitr, Phandee Wattanaboonyoungcharoen, Jérôme H. Kim, Sodsai Tovanabutra, Timothy W. Schacker, Robert J. O’Connell, Victor Valcour, Praphan Phanuphak, Merlin L. Robb, Nelson L. Michael, Lydie Trautmann, Nittaya Phanuphak, Jintanat Ananworanich, Nicolas Chomont,

HIV/AIDS Research and Interventions

Although a large pool of cells is infected during acute HIV infection, most of these early targets are rapidly cleared upon ART initiation.