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Some Applications of Spin Labels in the Study of Serum Albumin and Biomembranes

2008; Revista de Chimie; Volume: 59; Issue: 11 Linguagem: Inglês

10.37358/rc.08.11.2014

0034-7752

Gheorghe Benga, Ioana-Costina Dansoreanu, Maria Frangopol, Petre T. Frangopol,

Protein Interaction Studies and Fluorescence Analysis

The main contributions of the groups lead by the two main authors (Gh.B and P.T.F.) in the field of spin labeling ESR in studies of serum albumin and of some biomembranes are briefly described, mentioning some priorities. These are: the description in Romanian publications of the methodology for using spin labels in studies of proteins and biomembranes using the type ART-6 ESR spectrometer manufactured in Romania; the adaptation to this ESR spectrometer of a computerized system for the acqusition and processing of data; the application of a newly synthesized spin label, reactive with SH groups, in the study of serum albumin; the finding of the effects of 25-hydroxycholesterol at low concentrations (0,5-10 %) on egg yolk lecitin; the finding of a relatively high fluidity of human liver microsomes.