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Histological scoring systems in ulcerative colitis patients: a routine practice perspective

2020; Balkan Medical Union; Volume: 55; Issue: 1 Linguagem: Inglês

10.31688/abmu.2020.55.1.07

2558-815X

Anamaria CURTE, Gabriel Becheanu, Gabriel ANDREI, Florin Andrei, Catalina NICOLAE, Madalina CHIVU, Cristian Tieranu, Cristian Tieranu, Maria Sajin,

Mycobacterium research and diagnosis

Systèmes de grading histologique chez les patients atteints de colite ulcéreuse: une perspective pratique de routineIntroduction.La guérison histologique est devenue un objectif thérapeutique chez les patients atteints de colite ulcéreuse.Cependant, un consensus sur sa définition précise n'a pas encore été atteint.Un grand nombre de systèmes de grading histologique complexes pour la colite ulcéreuse sont disponibles dans la littérature, ce qui rend la standardisation compliquée.L'objectif de l'étude était d'identifier un système de grading histologique adapté à la pratique de routine et de contribuer ainsi à la standardisation du rapport histologique de l'activité inflammatoire dans la colite ulcéreuse.Matériaux et méthodes.Nous avons examiné rétrospectivement et noté 64 lames colorées H&E en utilisant l'index de Nancy (NI), le score Geboes (GS) et l'indice histopathologique Robarts (RHI) par trois pathologistes indépendants.Le niveau d'accord ABSTRACT Introduction.Histological healing has become a therapeutic goal in patients with ulcerative colitis.However, a consensus on its precise definition has not been reached yet.A large number of complex histological scoring systems for ulcerative colitis are available in literature making standardization a complicated issue.The objective of the study was to identify a histological scoring system that is adequate for routine practice and thus contributes to standardization of histological reporting of inflammation activity in ulcerative colitis.Materials and methods.We retrospectively reviewed and scored 64 H&E stained slides using Nancy index (NI), Geboes score (GS) and Robarts Histopathology Index (RHI).The level of inter-rater and intra-rater agreement, time needed for scoring per slide, and correlation between the histological scores and Mayo endoscopic score were further analysed statistically.Results.The inter-rater agreement was very good for NI (kappa=0.861)and GS (kappa=0.820),and moderate for RHI (kappa=0.592),p<0.005.The intra-rater agreement was very good for NI (kappa=0.973),GS