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Clinical Clues to Diagnose Amyloidosis

2019; Linguagem: Inglês

10.17659/01.2019.0069

2231-6809

Ronaldo Altenburg Gismondi, Fernanda Costa Azevedo, Larissa Baldassim Lopes, Alec Morse Blanz, Aline Oreiro da Silveira Pacheco, Luiz Felipe Costa Faria,

Pancreatitis Pathology and Treatment

Background: Amyloidosis is a rare systemic disease characterized by the deposition of an insoluble protein, amyloid, in various tissues and organs.The disease is more prevalent in the elderly and can affect any organ, including the kidneys, heart, muscles or skin.Furthermore, clinical manifestations may be easily identified during a physical examination and serve as a clue to the diagnosing amyloidosis as well as its etiology.Case Report: The present paper describes the case of an elderly man presenting with macroglossia, "shoulder pad" sign and periorbital ecchymosis.A presumptive diagnosis of amyloidosis in its primary form was made by the attending physician.Afterwards, bone marrow biopsy confirmed multiple myeloma as the underlying cause and the patient was treated with chemotherapy.Conclusion: Macroglossia, "shoulder pad" and periorbital ecchymosis are important physical examination clues to diagnosis and etiology of amyloidosis.