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Consensus statement from 2nd International Conference on Controversies in Vitamin D

2020; Springer Science+Business Media; Volume: 21; Issue: 1 Linguagem: Inglês

10.1007/s11154-019-09532-w

1573-2606

Andrea Giustina, Robert A. Adler, Neil Binkley, Jens Bollerslev, Roger Bouillon, Bess Dawson‐Hughes, Peter R. Ebeling, David Feldman, Anna Maria Formenti, Marise Lazaretti‐Castro, Claudio Marcocci, René Rizzoli, Chris Sempos, John P. Bilezikian,

Bone health and osteoporosis research

Abstract The 2 nd International Conference on Controversies in Vitamin D was held in Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address ongoing controversies and timely topics in vitamin D research, to review available data related to these topics and controversies, to promote discussion to help resolve lingering issues and ultimately to suggest a research agenda to clarify areas of uncertainty. Several issues from the first conference, held in 2017, were revisited, such as assays used to determine serum 25-hydroxyvitamin D [25(OH)D] concentration, which remains a critical and controversial issue for defining vitamin D status. Definitions of vitamin D nutritional status (i.e. sufficiency, insufficiency and deficiency) were also revisited. New areas were reviewed, including vitamin D threshold values and how they should be defined in the context of specific diseases, sources of vitamin D and risk factors associated with vitamin D deficiency. Non-skeletal aspects related to vitamin D were also discussed, including the reproductive system, neurology, chronic kidney disease and falls. The therapeutic role of vitamin D and findings from recent clinical trials were also addressed. The topics were considered by 3 focus groups and divided into three main areas: 1) “Laboratory”: assays and threshold values to define vitamin D status; 2) “Clinical”: sources of vitamin D and risk factors and role of vitamin D in non-skeletal disease and 3) “Therapeutics”: controversial issues on observational studies and recent randomized controlled trials. In this report, we present a summary of our findings.