Molecular Mechanisms of Parkinson's Disease
2019; Shefa Neuroscience Research Center; Volume: 8; Issue: 1 Linguagem: Inglês
10.29252/shefa.8.1.120
ISSN2345-4814
AutoresZeinab Rezaee, Mohammad Marandi, Hojjatallah Alaei, Fahimeh Esfarjani,
Tópico(s)Nerve injury and regeneration
ResumoIntroduction: Parkinson's disease is a common neurodegenerative disorder.In this disease, mitochondrial defects and oxidative s tress lead to the enhancement of the free radicals and the death of dopamine neurons in the Sabs tantia nigra.The clinical symptoms of this disease are including tremor, muscle s tiffness, and inability to walk as well as cognition, memory and learning deficits.Aging increases the severity of Parkinson's disease.Conclusion: Any therapeutic s trategy which can modulate antioxidant homeos tasis and neuroprotection may increase the life expectancy and quality of life of patients with Parkinson's disease.
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