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Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units

2020; Nature Portfolio; Volume: 26; Issue: 3 Linguagem: Inglês

10.1038/s41591-020-0792-9

1546-170X

Ha Uk Chung, Alina Y. Rwei, Aurélie Hourlier‐Fargette, Shuai Xu, KunHyuck Lee, Emma C. Dunne, Zhaoqian Xie, Claire Liu, Andrea S. Carlini, Dong Hyun Kim, Dennis Ryu, Elena V. Kulikova, Jingyue Cao, Ian C. Odland, Kelsey B. Fields, Brad Hopkins, Anthony Banks, Christopher Ogle, Dominic Grande, Jun Bin Park, Jong-Won Kim, Masahiro Irie, Hokyung Jang, Joo Hee Lee, Yerim Park, Jung-Woo Kim, Han Heul Jo, Hyoungjo Hahm, Raudel Avila, Yeshou Xu, Myeong Namkoong, Jean Won Kwak, Emily Suen, Max A. Paulus, Robin J. Kim, Blake V. Parsons, Kelia Human, Seung Sik Kim, Manish Patel, William Reuther, Tae Jun Yu, Sung Hoon Lee, John D. Leedle, Yeojeong Yun, Sarah Rigali, Taeyoung Son, Inhwa Jung, Hany Arafa, Vinaya Soundararajan, Ayelet Ollech, Avani Shukla, Allison Bradley, Molly Schau, Casey M. Rand, Lauren Marsillio, Z. Leah Harris, Yonggang Huang, Aaron Hamvas, Amy S. Paller, Debra E. Weese‐Mayer, Jong Yoon Lee, John A. Rogers,

Non-Invasive Vital Sign Monitoring

Standard clinical care in neonatal and pediatric intensive-care units (NICUs and PICUs, respectively) involves continuous monitoring of vital signs with hard-wired devices that adhere to the skin and, in certain instances, can involve catheter-based pressure sensors inserted into the arteries. These systems entail risks of causing iatrogenic skin injuries, complicating clinical care and impeding skin-to-skin contact between parent and child. Here we present a wireless, non-invasive technology that not only offers measurement equivalency to existing clinical standards for heart rate, respiration rate, temperature and blood oxygenation, but also provides a range of important additional features, as supported by data from pilot clinical studies in both the NICU and PICU. These new modalities include tracking movements and body orientation, quantifying the physiological benefits of skin-to-skin care, capturing acoustic signatures of cardiac activity, recording vocal biomarkers associated with tonality and temporal characteristics of crying and monitoring a reliable surrogate for systolic blood pressure. These platforms have the potential to substantially enhance the quality of neonatal and pediatric critical care. Soft electronic patches worn on the skin of infants or children in intensive-care units have a wide range of capabilities in aiding critical care, including monitoring of hemodynamic parameters, cardiac activity, movement and crying.