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Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNA

2020; Elsevier BV; Volume: 31; Issue: 6 Linguagem: Inglês

10.1016/j.annonc.2020.02.011

1569-8041

M.C. Liu, Geoffrey R. Oxnard, Eric A. Klein, Charles Swanton, Michael V. Seiden, Minetta C. Liu, Geoffrey R. Oxnard, Eric A. Klein, David A. Smith, Donald Richards, Timothy J. Yeatman, Allen Lee Cohn, Rosanna L. Lapham, Jessica Clément, Alexander S. Parker, Mohan K. Tummala, Kristi McIntyre, Mikkael A. Sekeres, Alan H. Bryce, Robert D. Siegel, Xuezhong Wang, David Cosgrove, Nadeem R. Abu‐Rustum, Jonathan C. Trent, David D. Thiel, Carlos Becerra, Manish Agrawal, Lawrence Garbo, Jeffrey K. Giguere, Ross M. Michels, Ronald P. Harris, Stephen Richey, Timothy A. McCarthy, David Waterhouse, Fergus J. Couch, Sharon Wilks, Amy Krie, Rama Balaraman, Alvaro Restrepo, Michael Meshad, Kimberly Rieger‐Christ, Travis Sullivan, Christine Lee, Daniel Greenwald, William Oh, Che‐Kai Tsao, Neil Fleshner, Hagen F. Kennecke, Maged Khalil, David R. Spigel, Atisha Manhas, Brian Ulrich, P. Kovoor, Christopher Stokoe, Jay Courtright, Habte A. Yimer, Timothy Larson, Charles Swanton, Michael V. Seiden, Steven R. Cummings, Farnaz Absalan, Gregory E. Alexander, Brian C. Allen, Hamed Amini, Alexander M. Aravanis, Siddhartha Bagaria, Leila Bazargan, John F. Beausang, Jennifer R. Berman, Craig Betts, Alexander W. Blocker, Joerg Bredno, Robert Calef, Gordon Cann, Jeremy G. Carter, Christopher Chang, Hemanshi Chawla, Xiaoji Chen, Tom C. Chien, Daniel Civello, Konstantin Davydov, Vasiliki Demas, Mohini Jangi, Dong Zhao, Saniya Fayzullina, Alexander P. Fields, Darya Filippova, Peter Freese, Eric T. Fung, Sante Gnerre, Samuel Gross, Meredith Halks‐Miller, Megan P. Hall, Anne‐Renee Hartman, Chenlu Hou, Earl Hubbell, Nathan Hunkapiller, Karthik A. Jagadeesh, Arash Jamshidi, Roger Jiang, Byoungsok Jung, Tae‐Hyung Kim, Richard D. Klausner, Kathryn N. Kurtzman, Mark Lee, Wendy Lin, Jafi A. Lipson, Hai Liu, Qin‐Wen Liu, Margarita Lopatin, Tara Maddala, M. Cyrus Maher, Collin Melton, Andrea Mich, Shivani Nautiyal, Jonathan Newman, Joshua Newman, Virgil Nicula, Cosmos Nicolaou, Ongjen Nikolic, Wenying Pan, Shilpen Patel, Sarah A. Prins, Richard P. Rava, Neda Ronaghi, Onur Sakarya, Ravi Vijaya Satya, Jan Schellenberger, Eric Scott, Amy J. Sehnert, Rita Shaknovich, Avinash Shanmugam, K. C. Shashidhar, Ling Shen, Archana Shenoy, Seyedmehdi Shojaee, Pranav Singh, Kristan K. Steffen, Susan Tang, Jonathan Toung, Anton Valouev, Oliver Venn, Richard T. Williams, Tony Wu, Hui Xu, Christopher Yakym, Xiao Yang, Jessica L. Yecies, Alexander S. Yip, Jack Youngren, Jeanne Yue, Jingyang Zhang, Lily Zhang, Lori Zhang, Nan Zhang, Christina Curtis, Donald A. Berry,

Genomic variations and chromosomal abnormalities

Early cancer detection could identify tumors at a time when outcomes are superior and treatment is less morbid. This prospective case-control sub-study (from NCT02889978 and NCT03085888) assessed the performance of targeted methylation analysis of circulating cell-free DNA (cfDNA) to detect and localize multiple cancer types across all stages at high specificity.