Produção Nacional
Revisado por pares
Ruthenium(II)‐Catalyzed Double Annulation of Quinones: Step‐Economical Access to Valuable Bioactive Compounds
2020; Wiley; Volume: 26; Issue: 48 Linguagem: Inglês
10.1002/chem.202001434
ISSN1521-3765
AutoresEufrânio N. da Silva Júnior, Renato L. Carvalho, Renata G. Almeida, Luísa G. Rosa, Felipe Fantuzzi, Torben Rogge, Pedro M. S. Costa, Cláudia Pessoa, Claus Jacob, Lutz Ackermann,
Tópico(s)Synthesis of Indole Derivatives
ResumoAbstract Double ruthenium(II)‐catalyzed alkyne annulations of quinones were accomplished. Thus, a strategy is reported that provides step‐economical access to valuable quinones with a wide range of applications. C−H/N−H activations for alkyne annulations of naphthoquinones provided challenging polycyclic quinoidal compounds by forming four new bonds in one step. The singular power of the thus‐obtained compounds was reflected by their antileukemic activity.
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