Produção Nacional
Cholestatic syndrome as initial manifestation of pancreatic metastasis of papillary thyroid carcinoma: case report and review
2020; Brazilian Society of Endocrinology and Metabolism; Linguagem: Inglês
10.20945/2359-3997000000215
ISSN2359-4292
AutoresMariana Yoshii Tramontin, Paulo Antônio Silvestre de Faria, Cristina Moreira do Nascimento, Cibele de Aquino Barbosa, Maria de Fátima Rei Pereira Barros, Aniela Rodrigues Gomes de Barros, Rafaela Cardoso de Carvalho, Antônio Kneipp Pitta de Castro, Fernanda Accioly de Andrade, Rossana Corbo, Fernanda Vaisman, Daniel Bulzico,
Tópico(s)Neuroendocrine Tumor Research Advances
ResumoSUMMARY Most papillary thyroid carcinomas (PTC) harbor excellent prognosis. Although rare, distant metastases normally occur in lungs and/or bones. Here we describe a rare case of pancreatic metastasis presenting with rapid onset cholestatic syndrome. A literature review was also performed. A 73-year-old man with a high risk PTC was submitted to total thyroidectomy (TT) followed by radioiodine therapy. After initial therapy, he persisted with progressive rising serum thyroglobulin levels but with no evidence of structural disease. Recently, the patient presented with a rapid onset and progressive cholestatic syndrome. A 4 cm lesion in pancreas was identified, with echoendoscopy fine-needle aspiration biopsy (FNAB) confirming a pancreatic metastasis from PTC. The patient was submitted to a successful pancreaticoduodenectomy. Pancreatic metastases of PTC are rare and few long-term follow-up data are available to guide management. Fourteen cases were former reported, mean age was 65.7 years-old with mean time between PTC and pancreatic metastasis diagnosis of 7.9 years. Nine of them had another distant metastasis, nine were diagnosed by FNAB and just two received sorafenib.
Referência(s)