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Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

2020; Cell Press; Volume: 181; Issue: 1 Linguagem: Inglês

10.1016/j.cell.2020.03.007

1097-4172

Lars Fugger, Lise Torp Jensen, Jamie Rossjohn,

Immunotherapy and Immune Responses

Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.