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Can IGF-1 Serum Levels Really be Changed by Acute Physical Exercise? A Systematic Review and Meta-Analysis

2020; Human Kinetics; Volume: 17; Issue: 5 Linguagem: Inglês

10.1123/jpah.2019-0453

1543-5474

Diego de Alcântara Borba, Eduardo da Silva Alves, João Paulo Pereira Rosa, Lucas Alves Facundo, Carlos Magno Amaral Costa, Aldo Coelho Silva, Fernanda Veruska Narciso, Andressa Silva, Marco Túlio de Mello,

Pituitary Gland Disorders and Treatments

Background : Physical exercise plays an important role in metabolic health, especially in the insulin-like growth factor-1 (IGF-1) system. The objective of this study was to perform a systematic review and meta-analysis to evaluate the effects of a single endurance and resistance exercise session on IGF-1 serum. Methods : The systematic review was performed in SPORTDiscus, MEDLINE, PubMed, and Google Scholar databases. All analyses are based on random-effect models. The study identified 249 records of which 21 were included. Results : There was an effect of endurance exercise on total IGF-1 ( P = .01), but not for free IGF-1 ( P = .36). Resistance exercise similarly only affected total IGF-1 ( P = .003) and not free IGF-1 ( P = .37). The effect size indicated that total IGF-1 is more affected (ES = 0.81) by endurance than by resistance exercise (ES = 0.46). The present study showed that IGF-1 serum concentrations are altered by exercise type, but in conditions which are not well-defined. Conclusions : The systematic review and meta-analysis suggest that there is no determinant in serum IGF-1 changes for the exercise load characteristic. Therefore, physical exercise may be an alternative treatment to control changes in IGF-1 metabolism and blood concentration.