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BIBTEX RIS

Fenbendazole Controls In Vitro Growth, Virulence Potential, and Animal Infection in the Cryptococcus Model

2020; American Society for Microbiology; Volume: 64; Issue: 6 Linguagem: Inglês

10.1128/aac.00286-20

1098-6596

Haroldo César de Oliveira, Luna S. Joffe, Karina Smidt Simon, Rafael F. Castelli, Flavia C. G. Reis, Arielle M. Bryan, Beatriz S. Borges, Lia Carolina Soares Medeiros, Anamélia Lorenzetti Bocca, Maurizio Del Poeta, Márcio L. Rodrigues,

Cytomegalovirus and herpesvirus research

The human diseases caused by the fungal pathogens Cryptococcus neoformans and Cryptococcus gattii are associated with high indices of mortality and toxic and/or cost-prohibitive therapeutic protocols. The need for affordable antifungals to combat cryptococcal disease is unquestionable. Previous studies suggested benzimidazoles as promising anticryptococcal agents combining low cost and high antifungal efficacy, but their therapeutic potential has not been demonstrated so far.