Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Topical pilocarpine for xerostomia in patients with head and neck cancer treated with radiotherapy

2020; Wiley; Volume: 26; Issue: 6 Linguagem: Inglês

10.1111/odi.13343

1601-0825

Raony Môlim de Sousa Pereira, Mônica Danielle Ribeiro Bastos, Maíra Peres Ferreira, Osvaldo de Freitas, Leandro Dorigan de Macedo, Harley Francisco de Oliveira, Hilton Marcos Alvez Ricz, Ana Carolina Fragoso Motta, Ana Paula Macedo, Camila Tirapelli, Vinícius Pedrazzi,

Oral health in cancer treatment

Abstract Objective To evaluate a pilocarpine spray as a treatment for xerostomia in patients treated with radiotherapy (RT) for head and neck cancer (HNC). Methods This was a placebo‐controlled, double‐blind, crossover clinical trial of patients complaining of dry mouth after RT for HNC. Forty patients were randomly assigned to either placebo or pilocarpine (1.54%) spray and instructed to use three times a day for 3 months. After 1‐month washout period, patients were crossed over to receive placebo or pilocarpine. The assessments were salivary flow (Stimulated Whole Saliva Flow – SWSF), xerostomia (Xerostomia Inventory – XI), and quality of life (QoL/Oral Health Impact Profile – OHIP‐14), assessed at baseline, 1 hr (only SWSF), and at 1, 2, and 3 months of treatment. Results Posttreatment SWFS was not statistically different between pilocarpine and placebo regardless of the treatment sequence (paired T test; p > .05), except for the SWFS rates at 2 months after therapy. When comparing pilocarpine with placebo in the time points, there was no significant difference ( p > .05) for QoL or XI. Significant differences in improvement in QoL and xerostomia experience appeared along time for pilocarpine group. Conclusion The topical application of pilocarpine spray tested was similar to placebo on SWSF assessments in patients treated with RT for HNC.