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Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Is Associated with Indigenous American Ancestry in Latin American Women

2020; American Association for Cancer Research; Volume: 80; Issue: 9 Linguagem: Inglês

10.1158/0008-5472.can-19-3659

1538-7445

Katie M. Marker, Valentina A. Zavala, Tatiana Vidaurre, Paul C. Lott, Jeannie Navarro Vásquez, Sandro Casavilca‐Zambrano, Mónica Calderón, Julio E. Abugattas, Henry Gómez, Hugo Fuentes, Ruddy Liendo-Picoaga, José M. Cotrina, Silvia P. Neciosup, Carlos A. Castañeda, Zaida Morante, Fernando Valencia, Javier Torres, Magdalena Echeverry, Mábel Bohórquez, Guadalupe Polanco‐Echeverry, Ana P. Estrada-Florez, Silvia J. Serrano‐Gómez, Jenny A. Carmona-Valencia, Isabel Alvarado‐Cabrero, María Carolina Sanabria‐Salas, Alejandro Velez-Zea, Jorge Donado, Sikai Song, Daniel R. Cherry, Lizeth I. Tamayo, Scott Huntsman, Donglei Hu, Roberto Ruiz‐Cordero, Ronald Balassanian, Elad Ziv, Jovanny Zabaleta, Luis G. Carvajal‐Carmona, Laura Fejerman,

Cancer-related Molecular Pathways

Women of Latin American origin in the United States are more likely to be diagnosed with advanced breast cancer and have a higher risk of mortality than non-Hispanic White women. Studies in U.S. Latinas and Latin American women have reported a high incidence of HER2 positive (+) tumors; however, the factors contributing to this observation are unknown. Genome-wide genotype data for 1,312 patients from the Peruvian Genetics and Genomics of Breast Cancer Study (PEGEN-BC) were used to estimate genetic ancestry. We tested the association between HER2 status and genetic ancestry using logistic and multinomial logistic regression models. Findings were replicated in 616 samples from Mexico and Colombia. Average Indigenous American (IA) ancestry differed by subtype. In multivariate models, the odds of having an HER2