Portal de Periódicos da CAPES

Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study

2020; Springer Science+Business Media; Volume: 39; Issue: 8 Linguagem: Inglês

10.1007/s10096-020-03870-3

1435-4373

Manuela Carugati, Stefano Aliberti, Giovanni Sotgiu, Francesco Blasi, Andrea Gori, Rosario Menéndez, Milena Encheva, Miguel Gallego, Pedro Leuschner, Silvia Ruiz-Buitrago, Salvatore Battaglia, Riccardo Fantini, Sergi Pascual-Guàrdia, Judith Marín‐Corral, Marcos I. Restrepo, Patricia Aruj, Silvia Attorri, Enrique Barimboim, Juan Pablo Caeiro, María Isabel Garzón, Victor Hugo Cambursano, Adrián Ceccato, Julio Chertcoff, Florencia Lascar, Fernando Di Tulio, Ariel Cordon Díaz, Lautaro De Vedia, María Cristina Ganaha, Sandra Lambert, Gustavo Lopardo, Carlos M. Luna, Alessio Gerardo Malberti, Nora Morcillo, Silvina Tártara, Claudia Pensotti, Betiana Pereyra, Pablo Scapellato, Juan Pablo Stagnaro, Sonali Shah, Felix Lötsch, Florian Thalhammer, Jean‐Louis Vincent, Kurt Anseeuw, Camille A Francois, Eva Van Braeckel, Marcel Zannou Djimon, Jules Bashi, Dodo Roger, Simone Aranha Nouér, Peter Chipev, Milena Encheva, Darina Miteva, Diana Petkova, Balkissou Adamou Dodo, Mbatchou Ngahane, Bertrand Hugo, Ning Shen, Jinfu Xu, Carlos Andres Bustamante Rico, Ricardo Buitrago, Fernando Jose Pereira Paternina, Kayembe Ntumba Jean-Marie, Vesna Vladic Carevic, Marko Jakopović, Mateja Janković, Zinka Matković, Ivan Mitrecic, Marie-Laure Bouchy Jacobsson, Anette Bro Christensen, Uff e Christian HeitmannBødtger, C Meyer, Andreas Vestergaard Jensen, Gertrud Baunbæk-knudsen, Pelle Trier Petersen, Stine Linding Andersen, Ibrahim El-Said Abd El-Wahhab, Nesreen Elsayed Morsy, Hanaa Shafiek, Eman Sobh, Fabrice Bertrand, Christian Brun‐Buisson, Étienne de Montmollin, Muriel Fartoukh, Jonathan Messika, Pierre Tattevin, Michael Dreher, Martin Kolditz, Matthias Meisinger, Mathias W. Pletz, Stefan Hagel, Jan Rupp, Tom Schaberg, Marc Spielmanns, Beatrice Siaw-Lartey, Katerina Dimakou, Dimosthenis Papapetrou, Evdoxia Tsigou, Dimitrios Ampazis, Mohit Bhatia, Raja Dhar, George D’Souza, Ravindra Kumar Garg, Parvaiz A Koul, P A Mahesh, BS Jayaraj, Kiran Vishnu Narayan, Hirennappa B Udnur, Shashi Bhaskara Krishnamurthy, Keihan Golshani, Vera M Keatings, Ignacio Martín‐Loeches, ‪Yasmin Maor‬‏, Jacob Strahilevitz, Salvatore Battaglia, Maria Carrabba, Piero Ceriana, Marco Confalonieri, Antonella d’Arminio Monforte, Bruno Del Prato, Marino De Rosa, Riccardo Fantini, Giuseppe Fiorentino, Maria Antonia Gammino, Francesco Menzella, Giuseppe Milani, Stefano Nava, Gerardo Palmiero, Roberta Petrino, Barbra Gabrielli, Paolo Giorgi Rossi, Claudio Sorino, Gundi Steinhilber, Alessandro Zanforlin, Kiyoyasu Kurahashi, Zeina Aoun Bacha, Daniel Barajas Ugalde, Omar Ceballos Zuñiga, José F Villegas, Milic Medenica, Ellen Garde, Deebya Raj Mihsra, Poojan Shrestha, Elliott Ridgeon, Babatunde Awokola, Ogonna Nwankwo, Adefuye Bolanle Olufunlola, Segaolu Olumide, Kingsley Nnanna Ukwaja, Muhammad Irfan, Łukasz Minarowski, Szymon Skoczyński, Felipe Froes, Pedro Leuschner, Mariana Meireles, Cláudia Ferrão, Pedro Leuschner, José Neves, Sofía Ravara, Cova da Beira, Victoria Brocovschii, Chesov Ion, Doina Rusu, Cristina Toma, Daniela Chirita, Alexei Birkun, Anna Kaluzhenina, Abdullah Almotairi, Zakeya Abdulbaqi, Ali Bukhary, Jameela Edathodu, Amal Fathy, Abdullah Mushira Abdulaziz Enani, Nazik Eltayeb Mohamed, Jawed Ulhadi Memon, Nada Bogdanović, Branislava Milenković, Dragica Pešut, Luis Borderías, Noel Manuel Bordon Garcia, Hugo Cabello Alarcón, Catia Cillóniz, Antoní Torres, Vicens Díaz-Brito, Xavier Casas, Alicia Encabo González, Maria Luisa Fernández-Almira, Miguel Gallego, Inmaculada Gaspar-GarcÍa, Juan González del Castillo, Patricia Javaloyes Victoria, Elena Laserna Martínez, Rosa Malo de Molina, Pedro J. Marcos, Rosario Menéndez, Ana PandoSandova, Cristina Prat, Alicia Lacoma del la Torre, Ignasi García-Olivé, Jordi Rello, Silvia Moyano, Francisco Sanz, Oriol Sibila, Ana Rodrigo‐Troyano, Jordi Solé‐Violán, Ane Uranga, Job F. M. van Boven, Ester Vendrell Torra, Jordi Almirall Pujol, Charles Feldman, Ho Kee Yum, Arnauld Attannon Fiogbe, F. Yangui, Semra Bilaçeroğlu, Levent Dalar, Ufuk Yılmaz, A. Ye. Bogomolov, Naheed Elahi, Devesh Dhasmana, Rhiannon Ions, Julie Skeemer, Gerrit Woltmann, Carole Hancock, Adam T. Hill, Banu Rudran, Silvia Ruiz-Buitrago, Marion Campbell, Paul Whitaker, Karen Allen, Verónica Brito, Jessica Dietz, Claire E Dysart, Susan M. Kellie, Ricardo A Franco-Sadud, Garnet Meier, Mina Gaga, Thomas L Holland, Stephen P. Bergin, Fayez Kheir, Mark Landmeier, Manuel Lois, Girish B. Nair, Hemali Patel, Luis Felipe Reyes, William Rodriguez-Cintron, Shigeki Saito, Nilam J. Soni, Julio Noda, Cecilia I Hinojosa, Stephanie M. Levine, Luis F. Angel, Antonio Anzueto, K. Scott Whitlow, John Hipskind, Kunal Sukhija, Richard G. Wunderink, Ray D Shah, Kondwelani Mateyo,

Respiratory viral infections research

An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p < 0.01). S. pneumoniae remains the most common pathogen in patients hospitalized with CAP. Multinational CPG recommendations for patients with CAP seem to appropriately cover the most common pathogens and should be strongly encouraged for the management of CAP patients.