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The RESOLUTE consortium: unlocking SLC transporters for drug discovery

2020; Nature Portfolio; Volume: 19; Issue: 7 Linguagem: Inglês

10.1038/d41573-020-00056-6

1474-1784

Giulio Superti‐Furga, Daniel H. Lackner, Tabea Wiedmer, Álvaro Inglés‐Prieto, Bárbara M. G. Barbosa, Enrico Girardi, Ulrich Goldmann, Bettina Gürtl, Kristaps Klavins, Christoph Klimek, Sabrina Lindinger, Eva Liñeiro-Retes, André C. Müller, Svenja Onstein, Gregor Redinger, Daniela Reil, Vitaly Sedlyarov, Gernot Wolf, Matthew Crawford, Robert A. Everley, David Hepworth, Shenping Liu, Stephen Noell, Mary Piotrowski, Robert V. Stanton, Hui Zhang, Salvatore Corallino, Andrea Faedo, Maria Insidioso, Giovanna Maresca, Loredana Redaelli, Francesca Sassone, Lia Scarabottolo, Michela Stucchi, Paola Tarroni, Sara Tremolada, Helena Batoulis, Andreas Becker, Eckhard Bender, Yung-Ning Chang, Alexander Ehrmann, Anke Müller‐Fahrnow, Vera Pütter, Diana Zindel, Bradford S. Hamilton, Martin Lenter, Diana Santacruz, Coralie Viollet, Charles E. Whitehurst, Kai Johnsson, Philipp Leippe, Birgit Baumgarten, Lena Chang, Yvonne Ibig, Martin Pfeifer, Jürgen Reinhardt, Julian Schönbett, Paul M. Selzer, Klaus Seuwen, Charles Bettembourg, Bruno Biton, Jörg Czech, Hélène de Foucauld, Michel Didier, Thomas Licher, Vincent Mikol, Antje Pommereau, Frédéric Puech, Veeranagouda Yaligara, A.M. Edwards, Brandon J. Bongers, Laura H. Heitman, Adriaan P. IJzerman, Hubert J. Sijben, Gerard J. P. van Westen, Justine M. Grixti, Douglas B. Kell, Farah Mughal, Neil Swainston, Marina Wright Muelas, Tina Bohstedt, N. Burgess-Brown, Liz Carpenter, Katharina L. Dürr, Jesper S. Hansen, Andreea Scacioc, Giulia Banci, Claire Colas, Daniela Digles, Gerhard F. Ecker, Barbara Füzi, Viktoria Gamsjäger, Melanie Grandits, Riccardo Martini, Florentina Troger, Patrick Altermatt, Cédric Doucerain, Franz Dürrenberger, Vania Manolova, Anna‐Lena Steck, Hanna Sundström, Maria Wilhelm, Claire M. Steppan,

Amino Acid Enzymes and Metabolism

The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class. The Innovative Medicines Initiative Consortium RESOLUTE has started to develop tools and produce data sets to de-orphanize transporters in the solute carrier protein (SLC) superfamily, thereby lowering the barrier for the scientific community to explore SLCs as an attractive drug target class.