Artigo Acesso aberto Produção Nacional Revisado por pares

Chemical composition, larvicidal and cytotoxic activities of the leaf essential oil of Bauhinia cheilantha (Bong.) Steud

2020; Elsevier BV; Volume: 131; Linguagem: Inglês

10.1016/j.sajb.2020.03.011

ISSN

1727-9321

Autores

A.M.A. Silva, Horlando C. Silva, Aliny Monteiro, Telma L. G. Lemos, Sadi Miranda De Souza, Gardênia Carmen Gadelha Militão, Hamilton V Santos, Péricles Barreto Alves, Nirla Rodrigues Romero, Gilvandete M. P. Santiago,

Tópico(s)

Insect Pest Control Strategies

Resumo

The essential oil obtained by hydrodistillation from fresh leaves of Bauhinia cheilantha was analysed by GC-FID and GC-MS. The chemical composition of the essential oil was dominated by sesquiterpenes (78.59%). The major components were identified as (E)-caryophyllene (21.65%), α-pinene (11.75%), spathulenol (4.84%) and caryophyllene oxide (4.62%). The larvicidal potential of the oil was evaluated against instar III larvae of Aedes aegypti, and showed LC50 value of 40.84 ± 0.87 μg/mL. The in vitro cytotoxic activity of the essential oil has been evaluated on pro-myelocytic leukemia (HL-60), lung carcinoma (NCI-H292), breast adenocarcinoma (MCF-7), and cervical adenocarcinoma (HEP-2) human tumor cell lines, and this analysis showed that the essential oil was more active against pro-myelocytic leukemia (HL-60) and breast adenocarcinoma (MCF-7) cell lines with IC50 values of 8.6 and 18.3 μg/mL, respectively. This is the first report on chemical composition, larvicidal and cytotoxic activities of this essential oil.

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