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Tumor cell death in orthotopic breast cancer model by NanoALA: a novel perspective on photodynamic therapy in oncology

2020; Future Medicine; Volume: 15; Issue: 10 Linguagem: Inglês

10.2217/nnm-2019-0458

1748-6963

Laise Rodrigues de Andrade, Antônio Cláudio Tedesco, Fernando Lucas Primo, Gabriel Ribeiro Farias, Da Silva, João Paulo Figueiró Longo, Marcos Célio de Almeida, Paulo EN de Souza, Ricardo Bentes Azevedo, Willie Oliveira Pinheiro, Zulmira GM Lacava,

Porphyrin and Phthalocyanine Chemistry

Aim: Nano-5-aminolevulic acid (NanoALA)-mediated photodynamic therapy (PDT), an oil-in-water polymeric nanoemulsion of ALA, was evaluated in a murine model of breast cancer. Materials & methods: Analysis of ALA-derived protoporphyrin IX production and acute toxicity test, biocompatibility and treatment efficacy, and long-term effect of NanoALA-PDT on tumor progression were performed. Results: The nanoformulation favored the prodrug uptake by tumor cells in a shorter time (1.5 h). As a result, the adverse effects were negligible and the response rates for primary mammary tumor control were significantly improved. Tumor progression was slower after NanoALA-PDT treatment, providing longer survival. Conclusion: NanoALA is a good proactive drug candidate for PDT against cancer potentially applied as adjuvant/neoadjuvant intervention strategy for breast cancer.