COVID-19: immunopathology and its implications for therapy
2020; Nature Portfolio; Volume: 20; Issue: 5 Linguagem: Inglês
10.1038/s41577-020-0308-3
ISSN1474-1741
Autores Tópico(s)Long-Term Effects of COVID-19
ResumoSevere coronavirus disease 2019 (COVID-19) is characterized by pneumonia, lymphopenia, exhausted lymphocytes and a cytokine storm. Significant antibody production is observed; however, whether this is protective or pathogenic remains to be determined. Defining the immunopathological changes in patients with COVID-19 provides potential targets for drug discovery and is important for clinical management. In the short time since SARS-CoV2 emerged, much has been learned about the immunopathology of the infection. Here, Xuetao Cao discusses what these early insights imply for drug discovery and clinical management.
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