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Metabolic reprogramming and cancer progression

2020; American Association for the Advancement of Science; Volume: 368; Issue: 6487 Linguagem: Inglês

10.1126/science.aaw5473

1095-9203

Brandon Faubert, Ashley Solmonson, Ralph J. DeBerardinis,

Epigenetics and DNA Methylation

Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but have not yet resulted in an effective anti cancer therapeutic. In a Review, Faubert et al. discuss how metabolism changes as cancer develops from a small, premalignant lesion to an aggressive primary tumor and then metastasizes. Metabolic vulnerabilities likely change with cancer progression, making the identification of general cancer-associated metabolic features difficult. The authors propose that a more targeted approach to tissues and vulnerabilities identified in patients may be more effective. Science , this issue p. eaaw5473