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Conjunctiva is not a preferred gateway of entry for SARS‐CoV‐2 to infect respiratory tract

2020; Wiley; Volume: 92; Issue: 9 Linguagem: Inglês

10.1002/jmv.25859

1096-9071

Zhe Liu, Chuan‐bin Sun,

COVID-19 Clinical Research Studies

Journal of Medical VirologyVolume 92, Issue 9 p. 1410-1412 LETTER TO THE EDITOR Conjunctiva is not a preferred gateway of entry for SARS-CoV-2 to infect respiratory tract Zhe Liu MD, Zhe Liu MD Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, ChinaSearch for more papers by this authorChuan-Bin Sun MD, PhD, Corresponding Author Chuan-Bin Sun MD, PhD [email protected] orcid.org/0000-0002-2767-6858 Division of Neuro-Ophthalmology, Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Correspondence Chuan-Bin Sun, MD, PhD, Division of Neuro-Ophthalmology, Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009 Zhejiang, China. Email: [email protected]Search for more papers by this author Zhe Liu MD, Zhe Liu MD Department of Ophthalmology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, ChinaSearch for more papers by this authorChuan-Bin Sun MD, PhD, Corresponding Author Chuan-Bin Sun MD, PhD [email protected] orcid.org/0000-0002-2767-6858 Division of Neuro-Ophthalmology, Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Correspondence Chuan-Bin Sun, MD, PhD, Division of Neuro-Ophthalmology, Eye Center, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009 Zhejiang, China. Email: [email protected]Search for more papers by this author First published: 10 April 2020 https://doi.org/10.1002/jmv.25859Citations: 32Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Xia J, Tong J, Liu M, Shen Y, Guo D. Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection. J Med Virol. 2020. https://doi.org/10.1002/jmv.25725 10.1002/jmv.25725 Web of Science®Google Scholar 2Sun CB, Wang YY, Liu GH, Liu Z. Role of the eye in transmitting human coronavirus: what we know and what we do not know. Front Public Health. 2020; 8: 155. https://doi.org/10.3389/fpubh.2020.00155 10.3389/fpubh.2020.00155 PubMedWeb of Science®Google Scholar 3Belser JA, Rota PA, Tumpey TM. Ocular tropism of respiratory viruses. Microbiol Mol Biol Rev. 2013; 77(1): 144-156. https://doi.org/10.1128/MMBR.00058-12 10.1128/MMBR.00058-12 CASPubMedWeb of Science®Google Scholar 4Peng Y, Zhou YH. Is novel coronavirus disease (COVID-19) transmitted through conjunctiva? [published online ahead of print March 16, 2020] J Med Virol. https://doi.org/10.1002/jmv.25753 Google Scholar 5Hamming I, Timens W, Bulthuis MLC, Lely AT, Navis GJ, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. 2004; 203(2): 631-637. https://doi.org/10.1002/path.1570 10.1002/path.1570 CASPubMedWeb of Science®Google Scholar 6Liu L, Sun Y, Pan X, Shen W, Liu ZY, Liu YP. Expression of SARS coronavirus S protein functional receptor-angiotensin-converting enzyme 2 in human cornea and conjunctiva. Chin Ophthal Res. 2004; 22(6): 561-564. CASGoogle Scholar 7Sun Y, Liu L, Pan X, Jing M. Mechanism of the action between the SARS-CoV S240 protein and the ACE2 receptor in eyes. Int J Ophthalmol. 2006; 6(4): 783-786. CASGoogle Scholar 8Lang J, Yang N, Deng J, et al. Inhibition of SARS pseudovirus cell entry by lactoferrin binding to heparan sulfate proteoglycans. PLoS One. 2011; 6(8):e23710. https://doi.org/10.1371/journal.pone.0023710 10.1371/journal.pone.0023710 CASPubMedWeb of Science®Google Scholar 9Milewska A, Nowak P, Owczarek K, et al. Entry of human coronavirus NL63 into the cell. J Virol. 2018; 92(3):e01933-17. https://doi.org/10.1371/journal.pone.0023710 10.1128/JVI.01933-17 PubMedWeb of Science®Google Scholar 10Deng W, Bao L, Gao H, et al. Ocular conjunctival inoculation of SARS-CoV-2 can cause mild COVID-19 in Rhesus macaques [published online ahead of print March 30, 2020]. bioRxiv. https://doi.org/10.1101/2020.03.13.990036 Google Scholar Citing Literature Volume92, Issue9Special Issue on New coronavirus (2019‐nCoV or SARS‐CoV‐2) and the outbreak of the respiratory illness (COVID‐19): Part‐VSeptember 2020Pages 1410-1412 ReferencesRelatedInformation