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On the Alert for Cytokine Storm: Immunopathology in COVID ‐19

2020; Wiley; Volume: 72; Issue: 7 Linguagem: Inglês

10.1002/art.41285

2326-5205

Lauren A. Henderson, Scott Canna, Grant S. Schulert, Stefano Volpi, Pui Y. Lee, Kate F. Kernan, Roberto Caricchio, Shawn A. Mahmud, Melissa M. Hazen, Olha Halyabar, Kacie J. Hoyt, Joseph Han, Alexei A. Grom, Marco Gattorno, Angelo Ravelli, Fabrizio De Benedetti, Edward M. Behrens, Randy Q. Cron, Peter A. Nigrović,

Autoimmune and Inflammatory Disorders Research

Poor outcomes in COVID-19 correlate with clinical and laboratory features of cytokine storm syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy may prevent immunopathology and could help conserve limited health care resources. While studies are ongoing, extrapolating from clinical experience in cytokine storm syndromes may benefit the multidisciplinary teams caring for patients with severe COVID-19.