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Non-coding RNAs and Coronary Artery Disease

2020; Springer Nature; Linguagem: Inglês

10.1007/978-981-15-1671-9_16

2214-8019

Alejandro Cardona-Monzonís, José Luis García‐Gimenez, Salvador Mena, Helios Pareja‐Galeano, Fernando de la Guía-Galipienso, Giuseppe Lippi, Federico V. Pallardó, Fabián Sanchis‐Gomar,

MicroRNA in disease regulation

Coronary artery disease (CAD) is the leading death cause worldwide. Non-coding RNA (ncRNA) are key regulators of genetic expression and thus can affect directly or indirectly the development and progression of different diseases. ncRNA can be classified in several types depending on the length or structure, as long non-coding RNA (lncRNA), microRNA (miRNA) and circularRNA (circRNA), among others. These types of RNA are present within cells or in circulation, and for this reason they have been used as biomarkers of different diseases, therefore revolutionizing precision medicine. Recent research studied the capability of circulating ncRNA to inform about CAD presence and predict the outcome of the disease. In this chapter we present a list of the miRNA, lncRNA and circRNA which are potential biomarkers of CAD.