Produção Nacional
Revisado por pares
Chemical composition and biological activities of the essential oils from Vitex-agnus castus, Ocimum campechianum and Ocimum carnosum
2020; Brazilian Academy of Sciences; Volume: 92; Issue: 1 Linguagem: Inglês
10.1590/0001-3765202020180569
ISSN1678-2690
AutoresLARA P. RICARTE, Gabrieli Penha Bezerra, Nirla Rodrigues Romero, Horlando Carlota da Silva, Telma L. G. Lemos, Ângela M. C. Arriaga, Péricles Barreto Alves, Marcelo Batista Dos Santos, Gardênia Carmen Gadelha Militão, Thiago D. S. Silva, Raimundo Braz‐Filho, Gilvandete M. P. Santiago,
Tópico(s)Phytochemistry and Biological Activities
ResumoThe essential oils obtained by hydrodistillation from fresh leaves of Vitex agnus-castus and Ocimum campechianum, and from fresh inflorescences of Ocimum carnosum were analysed by GC-FID and GC-MS. The major components of V. agnus-castus essential oil were identified as 1,8-cineole (47.9%), terpinyl α-acetate (11.6%), sabinene (11.2%) and caryophyllene oxide (9.7%), while in the O. campechianum essential oil were eugenol (72.1%), β-elemene (6.8%), (E)-caryophyllene (6.4%) and bicyclogermacrene (5.2%). Linalool (79.0%), α-epi-cadinol (5.4%), terpinen-4-ol (3.2%) and 1,8-cineole (2.8%) were the major constituents in the O. carnosum essential oil. The essential oils were subsequently evaluated for their larvicidal and cytotoxic activities. Larval bioassay against Aedes aegypti of V. agnus-castus, O. campechianum and O. carnosum essential oils showed LC50 values of 97.55 ± 0.35, 81.45 ± 0.35 and 109.49 ± 0.35 μg/mL, respectively. The in vitro cytotoxic activities of the essential oils has been evaluated on breast adenocarcinoma (MCF-7), lung carcinoma (NCI-H292), pro-myelocytic leukemia (HL-60), and cervical adenocarcinoma (HEP-2) human cell lines, and pro-myelocytic leukemia cells lines (HL-60) were found to be the most sensitive to all the essential oils tested than the others. This is the first report on larvicidal and cytotoxic activities of these essential oils.
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