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Cutaneous Clinico-Pathological Findings in three COVID-19-Positive Patients Observed in the Metropolitan Area of Milan, Italy

2020; Soc for Publication of Acta Dermato-Venereologica; Volume: 100; Issue: 8 Linguagem: Inglês

10.2340/00015555-3490

1651-2057

Raffaele Gianotti, Stefano Veraldi, Sebastiano Recalcati, Marco Cusini, Massimo Ghislanzoni, Francesca Boggio, Lindy P. Fox,

Autoimmune and Inflammatory Disorders

The novel coronavirus SARS-CoV-2/COVID-19 is rapidly and dramatically spreading throughout the world.We describe the clinical and histopathological features of 3 Italian patients with different cutaneous presentations of COVID-19 infection, observed and followed at the University of Milan. CASE REPORTSCase 1.A 59-year-old woman was admitted to the intensive care unit (ICU) at the University of Milan with bilateral interstitial pneumonia.Three days after admission, she developed widespread erythematous macules on arms, trunk and lower limbs (Fig. 1 A-C) that spontaneously improved within 5 days.C-reactive protein was 12 mg/l.Reverse transcriptase (RT)-PCR for COVID-19 virus was positive.Treatment was started with lopinavir-ritonavir, heparin and levofloxacin.She is currently recovering.Case 2. An 89-year-old woman was suffering from fever and cough of one-week duration.An exanthem on the trunk and arms was observed on admission at ICU (Fig. 1 D,E).Laboratory tests revealed mild increase in fibrinogen and transaminases.RT-PCR was positive for COVID-19 virus.Ceftriaxone and azithromycin were started.The exanthem improved spontaneously 8 days later.Case 3. A 57-year-old man in good general health acutely developed a widespread pruritic eruption of erythematous macules and papules (Fig. 1 F,G), followed two days later by fever, headache, cough and arthralgias.RT-PCR for COVID-19 virus was positive.Treatment with levofloxacin and hydroxychloroquine was started.