Portal de Periódicos da CAPES

Down syndrome: Distribution of brain amyloid in mild cognitive impairment

2020; Elsevier BV; Volume: 12; Issue: 1 Linguagem: Inglês

10.1002/dad2.12013

2352-8729

David B. Keator, Michael Phelan, Lisa Taylor, Eric Doran, Sharon J. Krinsky‐McHale, Julie C. Price, Erin E. Ballard, William Charles Kreisl, Christy Hom, Dana Nguyen, Margaret B. Pulsifer, Florence Lai, Diana Rosas, Adam M. Brickman, Nicole Schupf, Michael A. Yassa, Wayne Silverman, Ira T. Lott,

Dementia and Cognitive Impairment Research

Down syndrome (DS) is associated with a higher risk of dementia. We hypothesize that amyloid beta (Aβ) in specific brain regions differentiates mild cognitive impairment in DS (MCI-DS) and test these hypotheses using cross-sectional and longitudinal data.