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COVID-19–related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids

2020; American Thoracic Society; Volume: 202; Issue: 1 Linguagem: Inglês

10.1164/rccm.202003-0821oc

1535-4970

Michael C. Peters, Satria P. Sajuthi, Peter DeFord, Stephanie A. Christenson, Cydney Rios, Michael T. Montgomery, Prescott G. Woodruff, David T. Mauger, Serpil C. Erzurum, Mats W. Johansson, Loren C. Denlinger, Nizar N. Jarjour, Mario Castro, Annette T. Hastie, Wendy C. Moore, Victor E. Ortega, Eugene R. Bleecker, Sally E. Wenzel, Elliot Israel, Bruce D. Levy, Max A. Seibold, John V. Fahy,

Respiratory viral infections research

Coronavirus disease (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). ACE2 (angiotensin-converting enzyme 2), and TMPRSS2 (transmembrane protease serine 2) mediate viral infection of host cells. We reasoned that differences in ACE2 or TMPRSS2 gene expression in sputum cells among patients with asthma may identify subgroups at risk for COVID-19 morbidity.