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Diagnostic Accuracy of QuantiFERON-TB Gold Plus Assays in Children and Adolescents with Tuberculosis Disease

2020; Elsevier BV; Volume: 223; Linguagem: Inglês

10.1016/j.jpeds.2020.02.025

1097-6833

Aleix Soler-García, Anna Gamell, Begoña Santiago, Manuel Monsonís, Cristina Calvo, Elvira Cobo, Elena Colino, María Espiau, Carmelo Guerrero-Laleona, Zulema Lobato, Andrea Martín‐Nalda, Beatriz Pérez-Gorricho, Tomàs Maria Pérez-Porcuna, Ana Isabel Piqueras, Paula Rodríguez-Molino, Marta Ruiz, Antoni Soriano‐Arandes, Teresa Valmanya, Marc Tebruegge, Antoni Noguera‐Julián, Elena Colino, David Gómez‐Pastrana, M. A. Montero, Estrella Peromingo, Matilde Bustillo Alonso, Elisenda Moliner, Marina Fenoy, Marta Velásquez, Maria Queralt Soler, Lourdes García, Olga Calavia, Neus Rius, María Teresa Pascual, Pere Soler‐Palacín, Teresa Tórtola, Miguel Lillo, Marta Dapena, Eva María López-Medina, Marta Ruiz, María del Mar Polo de Santos, Ángel San Miguel Hernández, Teresa Hernández-Sanpelayo, Alfredo Tagarro, Ana Méndez‐Echevarría, María José Mellado, Fernando Baquero‐Artigao, Talía Sainz, Miluca García-Hortelano, Javier Álvarez, Enrique Villalobos, María Luz García‐García, M. Garrote, José Javier Korta Murua, Nerea Azurmendi Gundín, Laia Sánchez-Torrent, Eneritz Velasco‐Arnaiz, Clàudia Fortuny,

Infectious Diseases and Tuberculosis

In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. We conducted a cross-sectional multicenter study, involving 158 children and adolescents with tuberculosis disease. The overall sensitivity of the assay was 82.9% (IQR 77.0%-88.8%), indicating that in children this test does not have higher sensitivity than previous generation interferon-gamma release assays. In 2016, a new interferon-gamma release assay, QuantiFERON-TB Gold Plus, was introduced. We conducted a cross-sectional multicenter study, involving 158 children and adolescents with tuberculosis disease. The overall sensitivity of the assay was 82.9% (IQR 77.0%-88.8%), indicating that in children this test does not have higher sensitivity than previous generation interferon-gamma release assays.