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New cadinene-sesquiterpene from Chromolaena laevigata (lam.) R. M. King & H. Rob (Asteraceae) aerial parts and biological activities

2020; Taylor & Francis; Volume: 35; Issue: 21 Linguagem: Inglês

10.1080/14786419.2020.1747456

ISSN

1478-6427

Autores

Josiane A. Monteiro de Oliveira, Darlon I. Bernardi, Rodolfo Bento Balbinot, Márcia Regina Pereira Cabral, Érica Benassi Zanqueta, Eliana Harue Endo, Benedito Prado Dias Filho, Tânia Ueda‐Nakamura, Mariana Cecchetto Figueiredo, Ana Lúcia Tasca Góis Ruiz, Mary Ann Foglio, Marta Regina Barrotto do Carmo, María Helena Sarragiotto, Débora Cristina Baldoqui,

Tópico(s)

Natural product bioactivities and synthesis

Resumo

Phytochemical investigation of Chromolaena laevigata led to the isolation of a new cadinene-sesquiterpene, chromolaevigone glucoside (1), along with nine known compounds: daucosterol (2), stigmasterol glycoside (3), stigmasterol (4), β-sitosterol (5), pilloin (6), gonzalitosin I (7), quercetin-3-O-α-rhamnopyranoside (8), 7,7-dihydroxy-calamen-12-oic acid lactone (9) and trachelanthic acid (10). Others 11 known compounds were identified by UHPLC-HRMS/MS. These compounds are being described for the first time in this species, with the exception of cadinene 9. Furthermore, due to the limitation of pharmacological studies, antiproliferative, antiviral, and antimicrobial activities of C. laevigata were evaluated. The best results in the cytotoxicity, antimicrobial and antiproliferative tests, presenting GI50 values on ovarian tumour cells (OVCAR-03) of 1.9 μg mL-1 and kidney (786-0) of 2.5 μg mL-1 were observed for the hexanic fraction.[Figure: see text].

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