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COVID-19 and RAS: Unravelling an Unclear Relationship

2020; Multidisciplinary Digital Publishing Institute; Volume: 21; Issue: 8 Linguagem: Inglês

10.3390/ijms21083003

1661-6596

Damiano D’Ardes, Andrea Boccatonda, Ilaria Rossi, Maria Teresa Guagnano, Francesca Santilli, Francesco Cipollone, Marco Bucci,

SARS-CoV-2 and COVID-19 Research

The renin-angiotensin system (RAS) plays a main role in regulating blood pressure and electrolyte and liquid balance. Previous evidence suggests that RAS may represent an important target for the treatment of lung pathologies, especially for acute respiratory distress syndrome and chronic fibrotic disease. The scientific community has recently focused its attention on angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor 1 (AT1R) inhibitors and their possible benefit/harms for patients infected by Coronavirus disease (COVID-19) who experience pneumonia, but there are still some doubts about the effects of these drugs in this setting.