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Alternatives for the treatment of infections caused by ESKAPE pathogens
2020; Wiley; Volume: 45; Issue: 4 Linguagem: Inglês
10.1111/jcpt.13149
ISSN1365-2710
AutoresTaciéli F. da Rosa, Silvana Silveira Coelho, Vitória Segabinazzi Foletto, Angelita Bottega, Marissa Bolson Serafin, Catrine de Souza Machado, Laísa Nunes Franco, Bruno Rafael de Paula, Rosmari Hörner,
Tópico(s)Phenothiazines and Benzothiazines Synthesis and Activities
ResumoJournal of Clinical Pharmacy and TherapeuticsVolume 45, Issue 4 p. 863-873 COMMENTARY Alternatives for the treatment of infections caused by ESKAPE pathogens Taciéli Fagundes da Rosa PhD Student, Taciéli Fagundes da Rosa PhD Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorSilvana Silveira Coelho MSc, Silvana Silveira Coelho MSc Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorVitória Segabinazzi Foletto MSc Student, Vitória Segabinazzi Foletto MSc Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorAngelita Bottega PhD Student, Angelita Bottega PhD Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorMarissa Bolson Serafin PhD Student, Marissa Bolson Serafin PhD Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorCatrine de Souza Machado MSc, Catrine de Souza Machado MSc Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorLaísa Nunes Franco Pharmacy Student, Laísa Nunes Franco Pharmacy Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorBruno Rafael de Paula Pharmacy Student, Bruno Rafael de Paula Pharmacy Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorRosmari Hörner, Corresponding Author Rosmari Hörner rosmari.ufsm@gmail.com orcid.org/0000-0002-5513-4853 Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, Brazil Correspondence Rosmari Hörner, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. Email: rosmari.ufsm@gmail.comSearch for more papers by this author Taciéli Fagundes da Rosa PhD Student, Taciéli Fagundes da Rosa PhD Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorSilvana Silveira Coelho MSc, Silvana Silveira Coelho MSc Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorVitória Segabinazzi Foletto MSc Student, Vitória Segabinazzi Foletto MSc Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorAngelita Bottega PhD Student, Angelita Bottega PhD Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorMarissa Bolson Serafin PhD Student, Marissa Bolson Serafin PhD Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorCatrine de Souza Machado MSc, Catrine de Souza Machado MSc Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorLaísa Nunes Franco Pharmacy Student, Laísa Nunes Franco Pharmacy Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorBruno Rafael de Paula Pharmacy Student, Bruno Rafael de Paula Pharmacy Student Federal University of Santa Maria, Santa Maria, BrazilSearch for more papers by this authorRosmari Hörner, Corresponding Author Rosmari Hörner rosmari.ufsm@gmail.com orcid.org/0000-0002-5513-4853 Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, Brazil Correspondence Rosmari Hörner, Department of Clinical and Toxicological Analysis, Federal University of Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. Email: rosmari.ufsm@gmail.comSearch for more papers by this author First published: 27 April 2020 https://doi.org/10.1111/jcpt.13149Citations: 6Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract What is known and Objective The widespread use of antibiotics as therapeutic agents caused an increase of multidrug resistant bacteria (MDR) appearance. Regarding MDRs, we highlight the Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp.., which are the ESKAPE group. Comment New treatment alternatives for infections caused by ESKAPE are under current scientific research. The main suggestions are the use of actinomycetes that produce promising substances with antibiotic activity, the synergistic effect between antimicrobials and peptides, photoinactivation, peptide rich in cationic histidine, association of new antimicrobials; besides the repositioning of drugs already approved for the treatment of other diseases. What is New and Conclusion These selected studies showed that researchers from many countries are focused on the development of effective alternative strategies for the treatment of infections caused by these microorganisms. CONFLICT OF INTEREST The authors report no conflicts of interest. Citing Literature Volume45, Issue4August 2020Pages 863-873 RelatedInformation
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