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Lignin-Graft-Poly(lactic- co -glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis

2020; American Chemical Society; Volume: 5; Issue: 17 Linguagem: Inglês

10.1021/acsomega.0c00168

2470-1343

Carlos E. Astete, Judith U. De Mel, Sudipta Gupta, YeRim Noh, Markus Bleuel, Gerald J. Schneider, Cristina M. Sabliov,

Polymer composites and self-healing

A lignin-graft-poly(lactic-co-glycolic) acid (PLGA) biopolymer was synthesized with two types of lignin (LGN), alkaline lignin (ALGN) and sodium lignosulfonate (SLGN), at different (A/S)LGN/PLGA ratios (1:2, 1:4, and 1:6 w/w). 1H NMR and Fourier-transform infrared spectroscopy (FT-IR) confirmed the conjugation of PLGA to LGN. The (A/S)LGN-graft-PLGA biopolymers were used to form nanodelivery systems suitable for entrapment and delivery of drugs for disease treatment. The LGN-graft-PLGA NPs were generally small (100–200 nm), increased in size with the amount of PLGA added, monodisperse, and negatively charged (−48 to −60 mV). Small-angle scattering data showed that particles feature a relatively smooth surface and a compact spherical structure with a distinct core and a shell. The core size and shell thickness varied with the LGN/PLGA ratio, and at a 1:6 ratio, the particles deviated from the core–shell structure to a complex internal structure. The newly developed (A/S)LGN-graft-PLGA NPs are proposed as a potential delivery system for applications in biopharmaceutical, food, and agricultural sectors.