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Can a Cell Put Its Arms around a Memory?

2020; Elsevier BV; Volume: 26; Issue: 5 Linguagem: Inglês

10.1016/j.stem.2020.04.013

1934-5909

Teresa E. Knudsen, Joshua M. Brickman,

3D Printing in Biomedical Research

Summary Johnny Thunders once wrote, "You can't put your arms around a memory…" and the song continues, "don't try." Yet, when complex morphogenetic movements accompany differentiation, the cellular memory of signaling becomes essential. In this issue of Cell Stem Cell , Gunne-Braden et al. (2020) report a network wrapping its arms around the memory of BMP signaling, a phenomenon known as hysteresis.