Coeliac disease
1988; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-407-01320-9.50010-8
Autores Tópico(s)Vitamin K Research Studies
ResumoCeliac disease may be defined as a disease of the proximal small intestine characterized by an abnormal small-intestinal mucosa and associated with a permanent intolerance to gluten. The removal of gluten from the diet leads to a full clinical remission and restoration of the small-intestinal mucosa to normal. Celiac disease is a lifelong disorder that affects both children and adults. Environmental factors influence the incidence of celiac disease, because it cannot occur unless gluten is present in the child's diet. Hypoproteinemia is a common complication of celiac disease and is found in children with celiac disease is because of protein-losing enteropathy. When there is severe hypoproteinemia, the child may present with generalized edema mimicking the nephrotic syndrome. The edema is relieved by therapy that includes a gluten-free diet. An abnormal prothrombin time caused by the malabsorption of vitamin K may occur in celiac disease. Some authorities recommend calculating prothrombin time along with other parameters of coagulation before small-intestinal biopsy is performed.
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