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Adipokines in obesity

2013; Elsevier BV; Volume: 419; Linguagem: Inglês

10.1016/j.cca.2013.02.003

1873-3492

Viviane de Oliveira Leal, Denise Mafra,

Apelin-related biomedical research

White adipose tissue is recognized as a dynamic endocrine organ able to produce and release several bioactive polypeptides known as adipokines. Obesity is defined as an excessive growth of adipose tissue. As such, it is likely that adipokines could play an important role in the development of diseases associated with obesity including insulin resistance, inflammation, hypertension, cardiovascular risk and metabolic disorders. This review focuses on obesity specific-adipokine profiles and the role of some adipokines in obesity-related metabolic disorders.