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Detection of SARS-CoV-2-Specific Humoral and Cellular Immunity in COVID-19 Convalescent Individuals

2020; Cell Press; Volume: 52; Issue: 6 Linguagem: Inglês

10.1016/j.immuni.2020.04.023

1097-4180

Ling Ni, Fang Ye, Meng‐Li Cheng, Feng Yu, Yong‐Qiang Deng, Hui Zhao, Wei Peng, Jiwan Ge, Mengting Gou, Xiaoli Li, Lin Sun, Tian-Shu Cao, Pengzhi Wang, Chao Zhou, Rongrong Zhang, Liang Peng, Han Guo, Xinquan Wang, Cheng‐Feng Qin, Fang Chen, Chen Dong,

Long-Term Effects of COVID-19

The World Health Organization has declared SARS-CoV-2 virus outbreak a worldwide pandemic. However, there is very limited understanding on the immune responses, especially adaptive immune responses to SARS-CoV-2 infection. Here, we collected blood from COVID-19 patients who have recently become virus-free, and therefore were discharged, and detected SARS-CoV-2-specific humoral and cellular immunity in eight newly discharged patients. Follow-up analysis on another cohort of six patients 2 weeks post discharge also revealed high titers of immunoglobulin G (IgG) antibodies. In all 14 patients tested, 13 displayed serum-neutralizing activities in a pseudotype entry assay. Notably, there was a strong correlation between neutralization antibody titers and the numbers of virus-specific T cells. Our work provides a basis for further analysis of protective immunity to SARS-CoV-2, and understanding the pathogenesis of COVID-19, especially in the severe cases. It also has implications in developing an effective vaccine to SARS-CoV-2 infection.