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Antibody responses to SARS-CoV-2 in patients with COVID-19

2020; Nature Portfolio; Volume: 26; Issue: 6 Linguagem: Inglês

10.1038/s41591-020-0897-1

1546-170X

Quanxin Long, Bai-Zhong Liu, Haijun Deng, Gui-Cheng Wu, Kun Deng, Yao-Kai Chen, Pu Liao, Jingfu Qiu, Yong Lin, Xue-Fei Cai, De-Qiang Wang, Yuan Hu, Ji-Hua Ren, Ni Tang, Yinyin Xu, Li-Hua Yu, Zhan Mo, Fang Gong, Xiaoli Zhang, Wen-Guang Tian, Hu Li, Xian-Xiang Zhang, Jiang-Lin Xiang, Hong-Xin Du, Hua-Wen Liu, Chunhui Lang, Xiao-He Luo, Shao-Bo Wu, Xiao-Ping Cui, Zheng Zhou, Manman Zhu, Jing Wang, Cheng-Jun Xue, Xiao-Feng Li, Li Wang, Zhi-Jie Li, Kun Wang, Chang-Chun Niu, Qing-Jun Yang, Xiao-Jun Tang, Yong Zhang, Xia-Mao Liu, Jin-Jing Li, De-Chun Zhang, Fan Zhang, Ping Liu, Jun Yuan, Qin Li, Jieli Hu, Juan Chen, Ailong Huang,

SARS-CoV-2 detection and testing

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.