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Clinical relevance of lipid panel and aminotransferases in the context of hepatic steatosis and fibrosis as measured by transient elastography (FibroScan®)

2020; De Gruyter; Volume: 40; Issue: 1 Linguagem: Croata

10.5937/jomb0-24689

1452-8258

Luis Alberto Chi‐Cervera, Gordon Montalvo, M.E. Icaza-Chávez, Julio César Torres‐Romero, Víctor Ermilo Arana‐Argáez, Mario Alberto Ramírez-Camacho, Julio Lara‐Riegos,

Diet, Metabolism, and Disease

Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease and is associated with various co-morbidities. Transient elastography (FibroScan®) is a non-invasive method to detect NAFLD using the controlled attenuation parameter (CAP). We aimed to evaluate the association of the lipid panel and aminotransferases concentrations with the presence or absence of steatosis and fibrosis.One hundred and five patients with NAFLD were included. Hepatic steatosis was quantified by CAP (dB/m) and liver stiffness by Kilopascals (kPa), these values were then analyzed against patient lipid panel and serum concentrations of the liver enzymes aspartate aminotransferase (AST) and alanine aminotransferase (ALT). A correlation and multiple regression were used. Mann-Whitney U test was used as non-parametric analysis.We observed an association between hepatic steatosis and total cholesterol (B = 0.021, p = 0.038, Exp (B) = 1.021, I.C = 1.001-1.041) as well as serum triglycerides (B = 0.017, p = 0.006, Exp (B) = 1.018 and I.C = 1.005-1.030). Similarly, we found an association between significant hepatic fibrosis and lower concentrations of total cholesterol (B = -0.019, p = 0.005, Exp (B) = 0.982 I.C = 0.969-0.995) and elevated AST (B = 0.042, p = 3.25 × 10-4, Exp (B) = 1.043 I.C = 1.019-1.068) independent of age, gender and BMI.Our results suggest that, total cholesterol and triglyceride concentrations positively correlate with hepatic steatosis while significant hepatic fibrosis is associated with lower total cholesterol and higher AST concentrations.Oboljenje nealkoholna masna jetra (NAFLD) je jedan od najčešćih uzročnika hroničnog oboljenja koje je praćeno nizom različitih komorbiditeta. Kratkotrajna elastografija (FibroScan®) je neinvazivni metod za otkrivanje NAFLD primenom kontrolisanog prigušenog parametra (CAP). Namera je bila da se proceni veza između koncentracija lipidnog panela i aminotransferaza sa prisustvom ili odsustvom steatoze i fibroze.U ispitivanje je uključeno sto pedeset pacijenata sa NAFLD. Hepatična steatoza je merena pomoću CAP (dB/m) a krutost jetre pomoću kilopaskala (kPA), da bi zatim ove vrednosti bile analizirane prema vrednostima lipidnog panela i serumskih koncentracija jetrenih enzima aspartat aminotransferaze (AST) i alanin aminotransferaze (ALT). Za procenu su korišćena korelacija i multipla regresija. Mann-Whitney U test je korišćen kao ne-parametarska analiza.Posmatrana je veza između hepatične steatoze i ukupnog holesterola (B = 0,021, p = 0,038, Exp (B) = 1,021, I.C = 1,001-1, 041) kao i serumskih triglicerida (B = 0,017, p = 0,006, Exp (B) = 1,018 i I.C = 1,005-1,030). Nađena je slična veza između značajne hepatične fibroze i nižih koncentracija ukupnog holesterola (B = -0,019, p = 0,005, Exp(B) = 0,982, I.C = 0,969-0,995) i povišene AST (B = 0,042, P = 3.25 × 10-4, Exp (B) = 1,043, I.C = 1,019-1,068) nezavisno od starosti, pola i BMI.Dobijeni rezultati pokazuju da su koncentracije ukupnog holesterola i triglicerida u pozitivnoj korelaciji sa hepatičnom steatozom dok je značajna hepatična fibroza u vezi sa sniženim ukupnim holesterolom i višim koncentracijama AST.