Portal de Periódicos da CAPES

Artigo Produção Nacional Revisado por pares

BIBTEX RIS

Bioactive Compounds from the Aerial Parts of Evolvulus linarioides

2020; American Chemical Society; Volume: 83; Issue: 5 Linguagem: Inglês

10.1021/acs.jnatprod.9b01189

1520-6025

Laiane C. O. Pereira, Lucas Silva Abreu, Joanda P. R. e Silva, Francisca S. V. L. Machado, Cinthia S. Queiroga, Renan Fernandes do Espírito Santo, Diego Francisco de Agnelo-Silva, Cristiane Flora Villarreal, Maria de Fátima Agra, Marcus Tullius Scotti, Vicente Carlos de Oliveira Costa, Josean Fechine Tavares, Marcelo Sobral da Silva,

Traditional and Medicinal Uses of Annonaceae

Three new caryophyllane-type sesquiterpenoids, linariophyllenes A–C (1–3), two new hamamelitol derivatives, linaritols A (4) and B (5), two new chromones, linariosides A (6) and B (7), and three known chromones, cnidimol C (8), monnieriside A (9), and undulatoside A (10), were identified from the aerial parts of Evolvulus linarioides. The structures of these compounds were elucidated by NMR, MS, and IR data. The absolute configurations of compounds 1–5 and 7 were established via electronic circular dichroism data. The anti-inflammatory potential of compounds 1–5 and 7–10 was evaluated by determining their ability to inhibit the production of nitric oxide (NO) and proinflammatory cytokine IL-1β by stimulated J774 macrophages. Compounds tested at noncytotoxic concentrations inhibited NO production by macrophages, exhibiting IC50 values between 17.8 and 66.2 μM, and inhibited IL-1β production by stimulated macrophages by 72.7–96.2%.