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BIBTEX RIS

Comparison of salivary cytokines levels among individuals with Down syndrome, cerebral palsy and normoactive

2020; Medicina Oral S.L.; Linguagem: Inglês

10.4317/jced.56336

ISSN

1989-5488

Autores

CH Habibe, Ryotaro Yoshida, Renata Gorjão, Gabriela-Mancia Gutierrez, Débora Heller, Alexander Birbrair, Maria Teresa Botti Rodrigues Santos,

Tópico(s)

Diabetic Foot Ulcer Assessment and Management

Resumo

Background: Individuals with Down syndrome (DS) present increased susceptibility to infections and high prevalence of periodontal disease.The objective of this study is to evaluate the salivary concentrations of IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 of DS individuals and compare to cerebral palsy (CP) and normoactive patients (all with gingivitis).Material and Methods: Twenty-two individuals with DS, 24 with CP and 22 normoactive participated in this cross-sectional study.Salivary flow rate, osmolality rate, Oral Hygiene Index, Gingival Index (GI) and salivary inflammatory markers IL-1β, IL-6, IL-8, IL-10, TNFα and IL-12p70 were evaluated.Shapiro-Wilks, Chi-square, ANOVA One-Way and Kruskal Wallis tests were applied with significance level at 5%.Results: The groups were homogenous for gender, age, and IL12p70 cytokine (p>0.05).GI was significantly higher in DS compared to CP and healthy (p<0.05).CP presented reduced salivary flow and increased osmolality rate.CP showed significantly higher values for TNFα, IL10, and IL6 compared to DS and normoactive (p<0.05).DS and CP presented significantly higher values of IL-1β and IL8 compared to normoactive (p<0.05).

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