Portal de Periódicos da CAPES

Synthetic multicellularity

2012; Elsevier BV; Volume: 22; Issue: 12 Linguagem: Inglês

10.1016/j.tcb.2012.09.002

1879-3088

Michel M. Maharbiz,

Gene Regulatory Network Analysis

The ability to synthesize biological constructs on the scale of the organisms we observe unaided is probably one of the more outlandish, yet recurring, dreams humans have had since they began to modify genes. This review brings together recent developments in synthetic biology, cell and developmental biology, computation, and technological development to provide context and direction for the engineering of rudimentary, autonomous multicellular ensembles. The ability to synthesize biological constructs on the scale of the organisms we observe unaided is probably one of the more outlandish, yet recurring, dreams humans have had since they began to modify genes. This review brings together recent developments in synthetic biology, cell and developmental biology, computation, and technological development to provide context and direction for the engineering of rudimentary, autonomous multicellular ensembles.