Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Characterization and antibacterial activity of the essential oil obtained from the leaves of Baccharis coridifolia DC against multiresistant strains

2020; Elsevier BV; Volume: 145; Linguagem: Inglês

10.1016/j.micpath.2020.104223

ISSN

1096-1208

Autores

Priscilla Ramos Freitas, Ana Carolina Justino de Araújo, Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Janaína Esmeraldo Rocha, José Bezerra de Araújo Neto, Maria Milene Costa da Silva, Raimundo Luíz Silva Pereira, Luiz Everson da Silva, Wanderlei do Amaral, Cícero Deschamps, Saulo Relison Tintino, Jaime Ribeiro‐Filho, Henrique Douglas Melo Coutinho,

Tópico(s)

Ethnobotanical and Medicinal Plants Studies

Resumo

Essential oils are secondary metabolites with immense pharmacological potential.These substances are abundantly produced by plants of the family Asteraceae, such as Baccharis coridifolia. Previous studies have demonstrated that this species has pharmacological properties that make it a promising source of new antibacterial agents. Therefore, the present study aimed to evaluate the antibacterial and antibiotic-modulating activity of Baccharis coridifolia essential oil against multidrug-resistant (MDR) strains. The phytochemical analysis was carried out by gas chromatography coupled to Mass Spectroscopy (GC/MS), and realized the Minimum Inhibitory Concentation (MIC) and antibiotic-modulation from the microdilution method in 96-well plates. It was revealed the presence of germacrene D (23.7%), bicyclogermacrene (17.1%), and (E)-caryophyllene (8.4%) as major components. The minimum inhibitory concentration of essential oil against strains of Pseudomonas aeruginosa (512 μg/mL) and Staphylococcus aureus (128 μg/mL) demonstrated clinically relevant antibacterial activity. In addition, the combination of subinhibitory doses of the oil with conventional antibiotics showed synergism, indicating potentiation of the antibacterial effect. In conclusion, the essential oil of Baccharis coridifolia (EOBc) presented antibacterial and antibiotic-modulating activities that place this species as a source of molecules useful in the fight against bacterial resistance.

Referência(s)