Produção Nacional
Revisado por pares
Prediction of attempted suicide in men and women with crack-cocaine use disorder in Brazil
2020; Public Library of Science; Volume: 15; Issue: 5 Linguagem: Inglês
10.1371/journal.pone.0232242
ISSN1932-6203
AutoresVinícius Serafini Roglio, Eduardo Nunes Borges, Francisco Diego Rabelo-da-Ponte, Felipe Ornell, Juliana Nichterwitz Scherer, Jaqueline Bohrer Schuch, Ives Cavalcante Passos, Breno Sanvicente‐Vieira, Rodrigo Grassi‐Oliveira, Lísia von Diemen, Flávio Pechansky, Félix Henrique Paim Kessler,
Tópico(s)Forensic Toxicology and Drug Analysis
ResumoBackground Suicide is a severe health problem, with high rates in individuals with addiction. Considering the lack of studies exploring suicide predictors in this population, we aimed to investigate factors associated with attempted suicide in inpatients diagnosed with cocaine use disorder using two analytical approaches. Methods This is a cross-sectional study using a secondary database with 247 men and 442 women hospitalized for cocaine use disorder. Clinical assessment included the Addiction Severity Index, the Childhood Trauma Questionnaire, and the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, totalling 58 variables. Descriptive Poisson regression and predictive Random Forest algorithm were used complementarily to estimate prevalence ratios and to build prediction models, respectively. All analyses were stratified by gender. Results The prevalence of attempted suicide was 34% for men and 50% for women. In both genders, depression (PRM = 1.56, PRW = 1.27) and hallucinations (PRM = 1.80, PRW = 1.39) were factors associated with attempted suicide. Other specific factors were found for men and women, such as childhood trauma, aggression, and drug use severity. The men's predictive model had prediction statistics of AUC = 0.68, Acc. = 0.66, Sens. = 0.82, Spec. = 0.50, PPV = 0.47 and NPV = 0.84. This model identified several variables as important predictors, mainly related to drug use severity. The women's model had higher predictive power (AUC = 0.73 and all other statistics were equal to 0.71) and was parsimonious. Conclusions Our findings indicate that attempted suicide is associated with depression, hallucinations and childhood trauma in both genders. Also, it suggests that severity of drug use may be a moderator between predictors and suicide among men, while psychiatric issues shown to be more important for women.
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