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Increased antimutagenic and anticlastogenic effect of doenjang (Korean fermented soybean paste) prepared with bamboo salt

2007; Wiley; Volume: 21; Issue: 6 Linguagem: Inglês

10.1096/fasebj.21.6.a1078-a

1530-6860

Keun‐Ok Jung, Kyung‐Mi Hwang, Jeung‐Ha Kil, Young‐Eun Lee, Kun‐Young Park,

Phytoestrogen effects and research

The kind of salt used in doenjang (Korean fermented soybean paste) preparation is one of the most important factors to affect chemopreventive activity of doenjang. Bamboo salt (BS) is known to have various therapeutic effects on several diseases. In this study, antimutagenic and anticlastogenic effects of methanol extracts from doenjang prepared with BS were investigated in Ames test and micronucleus test. We compared 1 time heat treated BS added doenjang (BS1-D), 9 times heat treated BS added doenjang (BS9-D), sun-dried salt added doenjang (SDS-D) and purified salt added doenjang (PS-D). Especially, BS9-D inhibited aflatoxin B1-induced mutagenicity by 62%, a two-fold increase as compared to PS-D, at the lowest concentration (0.625 mg/plate) tested. BS1-D and BS9-D also showed higher inhibitory effects than PS-D and SDS-D on mutagenicity induced by N-methyl-N'-nitro-N-nitrosoguanidine and 4-nitroquinoline-1-oxide. SDS-D (500mg/kg) did not alter the induction of chromosome aberration by mitomycin C, while BS1-D extract (500mg/kg) significantly decreased the frequency of micronucleated reticulocytes (p<0.05). Even at 1000 mg/kg administration, BS1 exerted more suppressive effects on chromosome aberration than SDS-D. These results indicated that BS increased antimutagenicity and anticlastogenicity of doenjang and the kind of salt is an important factor to determine chemopreventive effect of doenjang.