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BCG vaccination–induced emergency granulopoiesis provides rapid protection from neonatal sepsis

2020; American Association for the Advancement of Science; Volume: 12; Issue: 542 Linguagem: Inglês

10.1126/scitranslmed.aax4517

1946-6242

Byron Brook, Danny Harbeson, Casey P. Shannon, Bing Cai, Daniel He, Rym Ben-Othman, Freddy Francis, Yue Z. Huang, Natallia Varankovich, Aaron C. Liu, Winnie Bao, Morten Bjerregaard-Andersen, Frederik Schaltz-Buchholzer, Lilica Sanca, Christian N Golding, Kristina Lindberg Larsen, Ofer Levy, Beate Kampmann, Rusung Tan, Adrian Charles, James L. Wynn, Frank Shann, Peter Aaby, Christine Stabell Benn, Scott J. Tebbutt, Tobias R. Kollmann, Nelly Amenyogbe, Amy Huei‐Yi Lee, Tue Bjerg Bennike, Joann Diray‐Arce, Olubukola T. Idoko, William Pomat, Simon D. van Haren, Momoudou Cox, Alansana Darboe, Reza Falsafi, Samuel J. Hinshaw, Jorjoh Ndure, Jainaba Njie-Jobe, Matthew A. Pettengill, Arnaud Marchant, Peter Richmond, Rebecca Ford, G Saleu, Geraldine Masiria, John Paul Matlam, Wendy Kirarock, Elishia Roberts, Mehrnoush Malek, Guzman Sánchez‐Schmitz, Amrit Singh, Asimenia Angelidou, Kinga K. Smolen, Ryan R. Brinkman, Al Ozonoff, Robert E. W. Hancock, Anita H.J. van den Biggelaar, Hanno Steen, Diana Vo, Ken Kraft, Kerry McEnaney, Sofia M. Vignolo,

Neonatal Respiratory Health Research

Neonatal administration of BCG vaccine rapidly increases neutrophil production to reduce mortality from sepsis.