Development of Ketone-Based Brominating Agents (KBA) for the Practical Asymmetric α-Bromination of Aldehydes Catalyzed by Tritylpyrrolidine
2020; American Chemical Society; Volume: 10; Issue: 11 Linguagem: Inglês
10.1021/acscatal.0c01596
ISSN2155-5435
AutoresAika Takeshima, Mio Shimogaki, Taichi Kano, Keiji Maruoka,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoKetone-based brominating agents (KBA), ortho-substituted 2,2,2-tribromoacetophenones, have been developed, and the highly enantioselective and practical α-bromination of aldehydes with KBA was achieved. The reaction could be performed in the presence of only 0.1–1 mol % of catalyst without using a halogenated solvent at 0 °C and was found to be scalable.
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