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Effects of 3‐Heptyl‐3,4,6‐trimethoxy‐3H‐isobenzofuran‐1‐one alone or/in association with cyclophosphamide on testicular function

2020; Wiley; Volume: 52; Issue: 7 Linguagem: Inglês

10.1111/and.13622

1439-0272

Rodrigo Juliano Oliveira, Andréa Luiza Cunha‐Laura, Caroline Amélia Gonçalves, Antônio Carlos Duenhas Monreal, Deiler Sampaio Costa, Alisson Meza, Dênis Pires de Lima, Adilson Beatriz, Ernani Aloysio Amaral, Sarah Alves Auharek,

Reproductive Biology and Fertility

AndrologiaVolume 52, Issue 7 e13622 ORIGINAL ARTICLE Effects of 3-Heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one alone or/in association with cyclophosphamide on testicular function Rodrigo Juliano Oliveira, Rodrigo Juliano Oliveira Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica (CeTroGen), Hospital Universitário Maria Aparecida Pedrossian (HUMAP), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorAndréa Luiza Cunha-Laura, Andréa Luiza Cunha-Laura Programa de Pós graduação em Farmácia, Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorCaroline Amélia Gonçalves, Caroline Amélia Gonçalves Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica (CeTroGen), Hospital Universitário Maria Aparecida Pedrossian (HUMAP), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorAntônio Carlos Duenhas Monreal, Antônio Carlos Duenhas Monreal Programa de Pós-Graduação em Ciências Veterinárias-CIVET, Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorDeiler Sampaio Costa, Deiler Sampaio Costa Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorAlisson Meza, Alisson Meza Instituto de Química (INQUI), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorDênis Pires de Lima, Dênis Pires de Lima Instituto de Química (INQUI), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorAdilson Beatriz, Adilson Beatriz Instituto de Química (INQUI), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorErnani Aloysio Amaral, Ernani Aloysio Amaral Faculdade de Medicina do Mucuri (FAMMUC), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Teófilo Otoni, BrasilSearch for more papers by this authorSarah Alves Auharek, Corresponding Author Sarah Alves Auharek sarahauharek@yahoo.com.br orcid.org/0000-0001-9164-0422 Faculdade de Medicina do Mucuri (FAMMUC), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Teófilo Otoni, Brasil Correspondence Sarah Alves Auharek, Faculdade de Medicina do Mucuri-FAMMUC, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rua do Cruzeiro, 01, Jardim São Paulo-Teófilo Otoni/MG, Brasil. Email: sarahauharek@yahoo.com.brSearch for more papers by this author Rodrigo Juliano Oliveira, Rodrigo Juliano Oliveira Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica (CeTroGen), Hospital Universitário Maria Aparecida Pedrossian (HUMAP), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorAndréa Luiza Cunha-Laura, Andréa Luiza Cunha-Laura Programa de Pós graduação em Farmácia, Faculdade de Ciências Farmacêuticas, Alimentos e Nutrição (FACFAN), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorCaroline Amélia Gonçalves, Caroline Amélia Gonçalves Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica (CeTroGen), Hospital Universitário Maria Aparecida Pedrossian (HUMAP), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorAntônio Carlos Duenhas Monreal, Antônio Carlos Duenhas Monreal Programa de Pós-Graduação em Ciências Veterinárias-CIVET, Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorDeiler Sampaio Costa, Deiler Sampaio Costa Faculdade de Medicina Veterinária e Zootecnia (FAMEZ), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorAlisson Meza, Alisson Meza Instituto de Química (INQUI), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorDênis Pires de Lima, Dênis Pires de Lima Instituto de Química (INQUI), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorAdilson Beatriz, Adilson Beatriz Instituto de Química (INQUI), Universidade Federal de Mato Grosso do Sul (UFMS), Campo Grande, BrasilSearch for more papers by this authorErnani Aloysio Amaral, Ernani Aloysio Amaral Faculdade de Medicina do Mucuri (FAMMUC), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Teófilo Otoni, BrasilSearch for more papers by this authorSarah Alves Auharek, Corresponding Author Sarah Alves Auharek sarahauharek@yahoo.com.br orcid.org/0000-0001-9164-0422 Faculdade de Medicina do Mucuri (FAMMUC), Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Teófilo Otoni, Brasil Correspondence Sarah Alves Auharek, Faculdade de Medicina do Mucuri-FAMMUC, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rua do Cruzeiro, 01, Jardim São Paulo-Teófilo Otoni/MG, Brasil. Email: sarahauharek@yahoo.com.brSearch for more papers by this author First published: 15 May 2020 https://doi.org/10.1111/and.13622Citations: 2Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Chemotherapy for cancer treatment may result in a temporary or long-term gonadal damage resulting in subfertility or infertility. Cyclophosphamide (CY) is a cytotoxic alkylating agent that has been widely used in the treatment of cancer. Recent studies have shown that synthetic resorcinol lipid AMS35AA (3-Heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one) may be an important adjuvant chemotherapy that potentiates mutagenic damage and increases apoptosis caused by CY. The present study investigates the action of AMS35AA alone or/in association with CY on testicular function. Animals were divided into four groups: (a) control group: received only water; (b) CY group: received 150 μg/g of CY b.w., i.p.; (c) AMS35AA group: received 10 μg/g of AMS35AA b.w., i.p; and (d) associated group: received 10 μg/g of AMS35AA + 150 μg/g of CY b.w., i.p. Four weeks after the treatment, the results showed that testes weight of CY and associated groups decreased. However, the number of Sertoli cell and Leydig cell per testis was similar in control and treated groups. Our findings provide strong evidence that the AMS35AA alone or in CY association is not toxic to spermatogenesis. The absence of toxicity of AMS35AA supports the view that the resorcinolic lipid could be used associated with CY chemotherapy without causing adverse effects to testes function. Citing Literature Volume52, Issue7August 2020e13622 RelatedInformation